Education

Ph.D., Korea University, 1999

MS, Korea University, 1991

BS, Korea University, 1989

Research Interest

I am interested in viral research on RSV and influenza (human, swine, and avian) universal vaccine development, targeting metastable viral fusion glycoproteins using virus-like particle (VLP) platforms and viral vectored vaccines generated through reverse genetics. My viral research focuses on viral vaccine development and host–virus interactions, with an emphasis on vaccine evaluation in small animal models, and on viral antigen epitope design to screen therapeutic monoclonal antibodies for viral infectious diseases, including Varicella zoster virus, JC virus, and norovirus, utilizing phage display technologies.

More recently, my work has expanded to the development of Bovine herpesvirus type 1 (BHV-1) virus vectored and pseudorabies virus vectored vaccines presenting multiple antigens for the prevention of viral infectious diseases in cattle.

Patents

Respiratory syncytial virus (rsv) vaccines; US20210052718A1

Publications

Young-Man Kwon, Hye Suk Hwang, Ki-Hye Kim, Young-Tae Lee, Eun-Ju Ko, Arun Meas, Sang-Moo Kang,” Virus-like Particle Vaccines Containing RSV Fusion Protein Cleavage Mutations Are Immunogenic and Protective in Cotton Rats With a Prime Dose”, Immune Network, 2025, 25(5), e37.

Park, Bo Ryoung, Subbiah, Jeeva, Kim, Ki-Hye, Kwon, Young-Man, Oh, Judy, Kim, Min-Chul, Shin, ChongHyun, Seong, Baik Lin, Kang, Sang-Moo, “Enhanced cross protection by hetero prime-boost vaccination with recombinant influenza viruses containing chimeric hemagglutinin-M2e epitopes”, Virology, 2022, 566, 143-152.

Park, Bo Ryoung, Kim, Ki-Hye, Kotomina, Tatiana, Kim, Min-Chul, Kwon, Young-Man, Jeeva, Subbiah, Jung,Yu-Jin, Bhatnagar, Noopur, Isakova-Sivak, Irina, Mezhenskaya, Daria, Rudenko, Larisa, Wang, Bao-Zhong, Kang, Sang-Moo, “Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin”, Scientific Reports, 2021, 11(1), 4151.

Kwon, Young-Man, Lee, Youri, Kim, Ki Hye, Jung, Yu Jin, Li, Zhuo, Jeeva, Subbiah, Lee, Sujin, Moore, Martin L, Kang, Sang-Moo, “Antigenicity and immunogenicity of unique prefusion-mimic F proteins presented on enveloped virus-like particles”, Vaccines(Basel), 2019, 37(44), 6656-6664

Kwon, Young-Man, Hwang, Hye Suk, Lee, Young-Tae, Kim, Ki-Hye, Lee, Youri, Kim, Min-Chul, Lee, Yu-Na,Quan, Fu-Shi, Moore, Martin L, Kang, Sang-Moo, “Respiratory Syncytial Virus Fusion Protein-encoding DNA Vaccine Is Less Effective in Conferring Protection against Inflammatory Disease than a Virus-like Particle Platform”, Immune Netw., 2019, 19(3), e18.

Kim, Yu-Jin, Kim, Ki-Hye, Ko, Eun-Ju, Kim, Min-Chul, Lee, Yu-Na, Jung, Yu-Jin, Lee, Young-Tae, Kwon,Young-Man, Song, Jae-Min, Kang, Sang-Moo, “Complement C3 Plays a Key Role in Inducing Humoral and Cellular Immune Responses to Influenza Virus Strain-Specific Hemagglutinin-Based or Cross-Protective M2 Extracellular Domain-Based Vaccination”, J Virol., 2018, 92(20).

Lee, Young-Tae, Kim, Ki-Hye, Hwang, Hye Suk, Lee, Youri, Kwon, Young-Man, Ko, Eun-Ju, Jung, Yu-Jin,Lee, Yu-Na, Kim, Min-Chul, Kang, Sang-Moo, “Innate and adaptive cellular phenotypes contributing to pulmonary disease in mice after respiratory syncytial virus immunization and infection”, Virology, 2015, 485, 36-46.

Lee, Yu-Na, Hwang, Hye Suk, Kim, Min-Chul, Lee, Young-Tae, Cho, Min-Kyoung, Kwon, Young-Man, Lee,Jong Seok, Plemper, Richard K, Kang, Sang-Moo, “Recombinant influenza virus carrying the conserved domain of respiratory syncytial virus (RSV) G protein confers protection against RSV without inflammatory disease”,Virology, 2015, 476, 217-225.

Kwon, Young-Man, Lee Jong Seok, Hwang, Hye Suk, Lee, Yu-Na, Ko, Eun-Ju, Yoo, Si-Eun, Kim, Min-Chul,Kim, Ki-Hye, Cho, Min Kyoung, Lee, Young-Tae, Lee, You Ri, Quan, Fu-Shi, Kang, Sang-Moo, “Baculovirus expressed virus-like particle vaccine in combination with DNA encoding the fusion protein confers protection against respiratory syncytial virus”, Vaccine, 2014, 32(44), 5866-5874.

Kwon, Young-Man, Hwang, Hye Suk. Lee, Jong Seok. Ko, Eun-Ju. Yoo, Si-Eun. Kim, Min-Chul. Lee, Yu-Na.Kim, Ki-Hye. Song, Jae-Min. Lee, Sujin. Moore, Martin L. Kang, Sang-Moo. “Maternal antibodies by passive immunization with formalin inactivated respiratory syncytial virus confer protection without vaccine-enhanced disease”, Antiviral Res., 2014, 104, 1-6.

PUBMED PUBLICATIONS